TAG-72 (BSB-21), MMab

Summary and Explanation

Tumor-associated glycoprotein (TAG-72) has been shown to be expressed in a wide variety of epithelial malignant tissues. TAG-72 antigen is a high molecular glycoprotein found on the surface of many cancer cells, including breast, colon and pancreatic cells. It is present in human Adenocarcinomas and in lesser amounts, non-neoplastic tissues. The majority of human Adenocarcinomas including Colorectal, Pancreatic, Gastric, Ovarian, Endometrial, Mammary, and Non-Small Cell Lung Cancer display some cell populations that are positive for TAG-72.

TAG-72 antibody has also been found to be useful for the distinction between Mesothelioma and Adenocarcinoma; however, false positive reactions can occur so results must be interpreted with the utmost caution.