TDP-43 / TARDBP (BSB-166), MMab
TDP-43 / TARDBP (BSB-166), MMab
Price:
$243.00
SKU:
BSB-3776-3
Antibody type:
Mouse Monoclonal
Clone:
BSB-166
Isotype:
IgG2a
Concentrate Dilution:
1:50-1:200
Localization:
Nuclear, Cytoplasmic
Tissue Control:
Breast, Fallopian Tube, Testis, Skin, TCC
Species Reactivity:
Human, Mouse, Rat, Horse, Dog, Bovine
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Transactive Response DNA binding protein 43 (TPD-43 or TARDBP) is an RNA and DNA binding protein in the heterogeneous nuclear ribonucleoprotein (hnRNP) family, where it regulates RNA associated with glucose and lipid metabolism.
TDP-43 antibody expression (TARDBP antibody) is associated with several neurodegenerative conditions amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) and metabolic regulation in cancer cells. TDP-43/TARDBP regulation of miRNAs has both tumor supporting and suppressive roles. Upregulation of TDP-43/TARDBP can lead to continued autophagy for survival and suppression of apoptosis pathways, promoting cancer cell survival under conditions of nutrient stress, as was seen in a study of glioblastomas. TDP-43/TARDBP and its targeted miRNAs have been associated with increased cell growth and migration in hepatocellular and lung cancers, but also with tumor inhibition in rhabdomyosarcomas through miRNA miR-500a-3p. TDP-43/TARDBP may also influence the function and targets of MiR-152, and miRNA associated with hepatocellular carcinoma, endometrial, gastric, and ovarian cancers. TDP-43/TARDBP has been found to be a novel oncogene in melanoma and regulates melanoma proliferation and metastasis potentially through modulation of glucose metabolism. TDP-43, has been found to promote triple-negative breast cancer (TNBC) progression.
Presentation
TDP-43 antibody is a mosue monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: tdp43, tdp-43, tdp 43, anti-tdp43, anti-tdp-43, anti-tdp 43, tardbp, anti-tardbp, transactive response dna binding protein 43
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB-3776-3 | $243.00 |
| Presentation: 7 ml Predilute | BSB-3776-7 | $433.00 |
| Presentation: 15 ml Predilute | BSB-3776-15 | $762.00 |
| Presentation: .1 ml Concentrate | BSB-3776-01 | $251.00 |
| Presentation: .5 ml Concentrate | BSB-3776-05 | $545.00 |
| Presentation: 1 ml Concentrate | BSB-3776-1 | $867.00 |
| Presentation: Control Slides [5] | BSB-3776-CS | $77.05 |
