Tri-Methyl-Histone H3(Lys27)/H3K27Me3 (RBT-H3K27Me3), RMab

Summary and Explanation

KDMA6A and B demethylases can act on H3K27Me, and loss-of-function mutations in these proteins have been found in solid and non-solid tumors including types of leukemia, lymphoma, melanoma, renal and bladder cancers, and in Medulloblastoma. As a gene transcription repressor, H3K27me3 has diverse roles in embryogenesis and neoplasia. Loss of H3K27me3 occurs in a significant subset of Malignant Peripheral Nerve Sheath tumors. Other neoplasms may show loss of H3K27me3 expression, such as Meningioma, Radiation Associated Unclassified Sarcoma, Radiation-Associated Angiosarcoma, Dedifferentiated Chondrosarcoma, Melanoma and Merkel Cell Carcinoma, amongst others. Some tumors may exhibit heterogeneous H3K27me3 expression (mosaic pattern).

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Synonyms: anti-Trimethyl Histone H3, anti Trimethyl Histone H3, unknown, anti-unknown, anti unknown, Histone H3, Histone H3