TRPS1 (EP392), RMab

Intended Use

For In Vitro Diagnostic Use

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The trichorhinophalangeal syndrome 1 (TRPS-1) gene belongs to the GATA transcription factor family. TRPS-1 has been identified as a highly prevalent gene in breast cancer, expressed in >90% of estrogen receptor alpha (ERα)+ and ERα− BC subtypes. As of today, the GATA3 tumor marker is commonly used to determine the breast origin for ER-positive and low-grade breast cancer, but is low in sensitivity <20% in metaplastic breast carcinoma such as Triple-Negative Breast Cancer (TNBC). In contrast, TRPS1 and GATA3 had comparable positive expression in ER-positive (98% vs. 95%) and HER2-positive (87% vs. 88%) breast carcinomas, but TRPS1 had higher expression than GATA3 in metaplastic (86% vs. 21%) and nonmetaplastic (86% vs. 51%) TNBC cases.