Zap-70 (2F3.2), MMab
Price:
$224.00
SKU:
BSB 6036
Antibody type:
Mouse Monoclonal
Clone:
2F3.2
Isotype:
IgG2a
Concentrate Dilution:
1:250-1:1000
Localization:
Cytoplasmic
Tissue Control:
Tonsil, Lymph Node, Thymus, CLL
Species Reactivity:
Human
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Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
ZAP-70 is an abbrevation for Zeta-chain-associated protein kinase 70 (70 is the molecular weight in kDa). The protein is a member of the protein-tyrosine kinase family. ZAP-70 is normally expressed in T-cells and natural killer cells and has a critical role in the initiation of T-cell signaling.
ZAP-70 antibody in B-cells is used as a prognostic marker in identifying different forms of Chronic Lymphocytic Leukemia (CLL). ZAP-70 protein is expressed in leukemic cells in approximately 25% of Chronic Lymphocytic Leukemia (CLL) cases as well. ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The ZAP-70 positive Ig-unmutated CLL cases have a poorer prognosis.
Presentation
ZAP-70 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: SRK, ZAP 70, ZAP70, anti-ZAP-70, anti ZAP-70, anti-ZAP 70, anti-ZAP70, anti ZAP 70, anti ZAP70, anti-SRK, anti SRK, 70 kDa zeta associated protein, FLJ17670, FLJ17679, STD, syk related tyrosine kinase, Tyrosine protein kinase ZAP 70, TZK, zeta chain TCR associated protein kinase 70kDa, zeta chain associated protein kinase 70kD, 70 kDa zeta chain associated protein
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 6036 | $224.00 |
| Presentation: 7 ml Predilute | BSB 6037 | $403.00 |
| Presentation: 15 ml Predilute | BSB 6038 | $726.00 |
| Presentation: .1 ml Concentrate | BSB 6039 | $168.00 |
| Presentation: .5 ml Concentrate | BSB 6040 | $460.00 |
| Presentation: 1 ml Concentrate | BSB 6041 | $612.00 |
| Presentation: Control Slides [5] | BSB-9431-CS | $101.00 |
