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alk1 alk-1 anti-alk1 anti-alk-1 alk anti-alk cd246 anti-cd246 anaplastic lymphoma kinase antibody immunohistochemistry i MAIN

ALK-1 / CD246 (RBT-ALK1), RMab

Presentation:

Price: $251.00

SKU:	BSB 5043
Antibody type:	Rabbit Monoclonal
Clone:	RBT-ALK1
Isotype:	IgG
Concentrate Dilution:	1:100-1:500
Localization:	Cytoplasmic, Nuclear
Tissue Control:	Anaplastic Large Cell Lymphoma
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Anaplastic Lymphoma Kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 t(2;5), the ALK gene fuses with the NPM gene. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80 kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK.

ALK-1 antibody recognizes a human p80 protein, identified as a hybrid of the Anaplastic Lymphoma Kinase (ALK) gene and the Nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of Large-Cell Lymphomas. ALK-1 is detected in 60% of Anaplastic Large-Cell Lymphomas and has proven to indicate a better prognosis in the ALK-1 (+) group.

Presentation

ALK-1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: CD246, ALK, anti-ALK, anti ALK, ALK Receptor Tyrosine Kinase (RTK), anti-ALK Receptor Tyrosine Kinase (RTK), anti ALK Receptor Tyrosine Kinase (RTK), ALK RTK, type 1 receptor tyrosine kinase ALK, anti-CD246, anti CD246, anti-ALK RTK, anti ALK RTK, anti-type 1 receptor tyrosine kinase ALK, anti type 1 receptor tyrosine kinase ALK, anaplastic lymphoma receptor tyrosine kinase, NBLST3, alk-1, anti-alk-1, anti-alk1, alk1

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 5043	$251.00
Presentation: 7 ml Predilute	BSB 5044	$455.00
Presentation: 15 ml Predilute	BSB 5045	$823.00
Presentation: .1 ml Concentrate	BSB 5046	$281.00
Presentation: .3 ml Concentrate	BSB 5047	$618.00
Presentation: 1 ml Concentrate	BSB 5048	$945.00
Presentation: Control Slides [5]	BSB-9010-CS	$170.00