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Arginase-1 (EP261), RMab

Presentation:

Price: $225.00

SKU:	BSB 2447
Antibody type:	Rabbit Monoclonal
Clone:	EP261
Isotype:	IgG
Concentrate Dilution:	1:50-1:200
Localization:	Cytoplasmic, Nuclear
Tissue Control:	Liver, Hepatocellular Carcinoma
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Arginase-1 is the catalyst for the fifth and final step in the urea cycle, which is a series of biochemical reactions in mammals during which the body disposes of harmful ammonia. Arginase-1 works to convert L-arginine into L-ornithine and urea. Arginise-1 is located primarily in the cytoplasm of the liver. Arginase-1 consists of three tetramers, and the enzyme requires a two-molecule metal clusterof manganese in order to maintain proper function. These Mn2+ ions coordinate with water, orienting and stabilizing the molecule and allowing water to act as anucelophile and attack L-arginine, hydrolyzing it into ornithine and urea.

Arginase-1 antibody is abundantly expressed in the liver and it represents a sensitive and specific marker of benign and malignant hepatocytes. In sections of normal liver, anti-arginase 1 produces strong, diffuse cytoplasmic reactivity in all hepatocytes throughout the lobule. In a small percentage of cases, patchy nuclear reactivityis also evident in hepatocytes along with the strong cytoplasmic reactivity. Hepatocellular carcinoma usually shows higher protein expression of ARG1 than normal liver cells.

Presentation

Arginase-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: ARG1, arginase liver, arginase 1, Liver type arginase, type I arginase, anti-arginase, anti-arginase-1, anti arg1, anri-arg1, anti-arg

Specification Sheets

IVD - CE

Safety Data Sheets

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 2447	$225.00
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Presentation: 15 ml Predilute	BSB 2449	$750.00
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