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brg-1, brg1, anti-brg-1, anti-brg1, smarca-4, anti-smarca-4, smarca4, anti-smarca4 MAIN

BRG-1 (BSB-154), MMab

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Price: $227.00

SKU:	BSB-3714-3
Antibody type:	Mouse Monoclonal
Clone:	BSB-154
Isotype:	IgG1
Concentrate Dilution:	1:25-1:100
Localization:	Nuclear
Tissue Control:	Colon, Kidney, Prostate, Testis, TCC
Species Reactivity:	Human, Mouse, Rat

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Brahma-related gene-1 (BRG-1) protein is encoded by the gene SMARCA-4, which is localized on chromosome 19. BRG-1 is the core catalytic ATPase subunit of the SWItch/sucrose non-fermentable (SWI/SNF) complex. SWI/SNFs are a member of the family of ATP-dependent chromatin-remodeling complexes and the function of SWI/SNFs is to facilitate the transcriptional activation or repression of target genes. BRG-1 is essential for DNA repair, differentiation, and organ development. The molecular weight of the BRG-1 subunit is approximately 185 kDa.

There are several studies that suggest the involvement of BRG-1 in different cancer types. It was found that the loss of BRG-1 antibody expression occurs in a portion of tested cancers types, including Breast, Colon, Head/Neck, Ovarian, Liver and Renal Cell Cancer. On the contrary, overexpression of BRG-1 was found in Breast, Colorectal, and Prostate Cancer, as well as Melanoma and Neuroblastoma. An IHC analysis of BRG-1 in Non-Small Cell Lung Cancer (NSCLC) patients revealed that the survival rate of BRG-1 negative patients was 0%, when compared to BRG-1 positive patients, indicating the prognostic value of BRG-1 as a biomarker. Other IHC studies found that the loss of BRG-1 protein expression highly correlates with Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT), suggesting BRG-1 as a diagnostic marker for SCCOHT.

Synonyms: brg-1, brg1, anti-brg-1, anti-brg1, smarca-4, anti-smarca-4, smarca4, anti-smarca4, brg.1, anti-brg.1

Specification Sheets

IVD

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3714-3	$227.00
Presentation: 7 ml Predilute	BSB-3714-7	$408.00
Presentation: 15 ml Predilute	BSB-3714-15	$717.00
Presentation: .1 ml Concentrate	BSB-3714-01	$236.00
Presentation: .5 ml Concentrate	BSB-3714-05	$515.00
Presentation: 1 ml Concentrate	BSB-3714-1	$848.00
Presentation: Control Slides [5]	BSB-9038-CS	$101.00

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BRG-1 (BSB-154), MMab

Intended Use

Summary and Explanation

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