Navigate:

StoreFront / Immunohistochemistry / Antibodies / All Antibodies / Cathepsin K (BSB-172), MMab

<		Previous Product
		Next Product		>

CTSK, anti-cathepsin K, anti cathepsin K, anti-CTSK, anti CTSK, cathepsin K, cathepsin X MAIN

Cathepsin K (BSB-172), MMab

Presentation:

Price: $190.67

SKU:	BSB-3800-3
Antibody type:	Mouse Monoclonal
Clone:	BSB-172
Isotype:	IgG1, kappa
Concentrate Dilution:	1:25-1:100
Localization:	Cytoplasmic
Tissue Control:	Breast, Liver
Species Reactivity:	Human

DescriptionDocumentationAsk a QuestionPrice Details

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Cathepsin K is a cysteine protease, which may be secreted as a pro-enzyme and is activated in a low-pH environment such as lysosomes. Cathepsin K accepts Arg and Lys residues at the P1 active site, acting on Proteolytically Activated Receptors (PARs) in extracellular matrix. Cathepsin K also cleaves collagen and degrades bone matrix, and is involved in the mTOR signaling pathway of cellular autophagy and apoptosis. Cathepsin K has also been shown to play a role in MHC II antigen presentation, keratinocyte differentiation, platelet aggregation, and in the Hedgehog signaling pathway.

As a protease active in the extracellular matrix and lysosomes, Cathepsin K has been implicated in cancer progression and invasiveness. Cathepsin K has been shown to have specific proteolytic activity on PAR-3 and PAR-4, which are expressed in the EMC of epithelial-mesenchymal cells in breast cancer. Proteolytic cleavage of PARs stimulates platelet aggregation and p38 phosphorylation in the MAPK pathway.

Cathepsin K-induced proteolytic cleavage induces upregulation of proteins related to metastasis in bone and prostate cancer, and epithelial-mesenchymal-like cells in breast cancer.

Synonyms: CTSK, anti-cathepsin K, anti cathepsin K, anti-CTSK, anti CTSK, cathepsin K, cathepsin O, cathepsin O1, Cathepsin O2, cathepsin X

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

There are currently no questions about this product.
Ask a Question

Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3800-3	$190.67
Presentation: 7 ml Predilute	BSB-3800-7	$286.00
Presentation: 15 ml Predilute	BSB-3800-15	$478.34
Presentation: .1 ml Concentrate	BSB-3800-01	$190.67
Presentation: .5 ml Concentrate	BSB-3800-05	$383.00
Presentation: 1 ml Concentrate	BSB-3800-1	$669.00
Presentation: Control Slides [5]	BSB-9438-CS	$67.00

(805) 692-2768

sales@biosb.com

Returning Customer?

Shopping Cart

The Shopping Cart is currently empty

Enter Coupon

Secure Checkout

Cathepsin K (BSB-172), MMab

Intended Use

Summary and Explanation

Subscribe to our mailing list