CD10 (EP195), RMab

Summary and Explanation

CD10, also known as neutral endopeptidase (NEP), Neprilysin, and common Acute Lymphoblastic Leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer’s Disease.

CD10 antibody is a useful marker for the characterization of childhood Leukemia and B-cell Lymphomas. This antibody reacts with the antigens of Lymphoblastic, Burkitt’s, and Follicular Lymphomas, and Chronic Myelocytic Leukemia. Also, CD10 antibody detects the antigen of glomerular epithelial cells and the brush border of the proximal tubules. This characteristic may be helpful in interpreting renal ontogenesis in conjunction with other markers. Other non-lymphoid cells that are reactive with CD10 are breast myoepithelial cells, bile canaliculi, neutrophils, a small population of bone marrow cells, fetal small intestine epithelium, and normal fibroblasts.