CD73 (RM431), RMab

Summary and Explanation

In a study that analyzed several publications conducting IHC analysis, CD73 antibody overexpression was found to be associated with several types of human cancers including Bladder, Brain, Invasive Lobular Breast, Esophageal, Gastric, Pancreatic, Rectal mucinous, Renal Cell, Lung Large Cell, oral cavity Squamous Cell, Melanoma, and Lung Adenocarcinoma Cancers. Studies also found that lymph node metastases correlated with high CD73 expression. One study investigated CD73 in Non-Small Cell Lung Cancer (NSCLC) tissues by IHC and found that CD73 expression is frequently higher in NSCLC tissue, compared to normal tissue, which indicates the prognostic value of CD73 in the tumorigenesis of NSCLC. Another study revealed the prognostic potential of CD73 antibody as a biomarker in Breast Cancer, since CD73 is associated with cancer cell invasion, migration and lymph node metastasis. Other studies showed a positive correlation between CD73 expression with Colorectal Cancer malignancy, and metastatic Melanomas

---

Synonyms: cd73, anti-cd73, nt5e, anti-nt5e, Ecto-5’-nucleotidase, anti-Ecto-5’-nucleotidase