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Chromogranin A (LK2H10), MMab
SKU: |
BSB 5344 |
Antibody type:
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Mouse Monoclonal
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Clone:
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LK2H10
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Isotype:
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IgG1/K
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Concentrate Dilution:
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1:250-1:1000
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Localization:
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Cytoplasmic
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Tissue Control:
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Pancreas, Pituitary, Colon, Brain
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Species Reactivity:
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Human, Dog, Cat, Rat, Rabbit, Porcine
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Chromogranin A is a member of the chromogranin/secretogranin family of neuroendocrine secretory pro-teins. Examples of cells producing chromogranin A are the adrenal medulla, enterochromaffin-like cells and beta cells of the pancreas. The function of chromogranin A is unknown but it is a precursor to 3 functional peptides: vasostatin, pancreastatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine).
Chromogranin A antibody is an excellent marker for Carcinoid Tumors, Pheochromocytomas, Paragangliomas, and other Neuroendocrine Tumors. Coexpression of chromogranin A and neuron-specific enolase (NSE) is common in neuroendocrine neoplasms. It has been identified in a wide variety of endocrine tissues including the pituitary, pancreas, hypothalamus, thymus, thyroid, intestine and parathyroid. It is generally accepted that the coexpression of certain keratins and chromogranin means neuroendocrine lineage. The presence of strong chromogranin antibody staining and absence of keratin staining should raise the possibility of paraganglioma. Most pituitary adenomas and prolactinomas readily express chromogranin.
Presentation
Chromogranin A antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: Chr A, ChrA, CHGA, anti-Chr-A, anti Chr-A, anti-Chr A, anti-ChrA, anti Chr A, anti ChrA, Chromogranin A, anti-Chromogranin A, anti Chromogranin A, anti-CHGA, anti CHGA, chromogranin A parathyroid secretory protein 1, CGA
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 5344 | $123.00 |
Presentation: 7 ml Predilute | BSB 5345 | $163.00 |
Presentation: 15 ml Predilute | BSB 5346 | $317.00 |
Presentation: .1 ml Concentrate | BSB 5347 | $136.00 |
Presentation: .5 ml Concentrate | BSB 5348 | $284.00 |
Presentation: 1 ml Concentrate | BSB 5349 | $474.00 |
Presentation: Control Slides [5] | BSB-9118-CS | $77.00 |
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