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Cytokeratin 17 (BSB-33), MMab
SKU: |
BSB 2726 |
Antibody type:
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Mouse Monoclonal
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Clone:
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BSB-33
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Isotype:
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IgG2b
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Concentrate Dilution:
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1:25-1:100
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Localization:
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Cytoplasmic
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Tissue Control:
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Skin, Testis, Breast, Cervical Ca., Bladder TCC
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Species Reactivity:
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Human, Rat, Goat and Pig
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Cytokeratin 17 (CK17) is a mouse monoclonal antibody for immunohistochemistry from Bio SB. Cytokeratin 17 is a Type I cytokeratin with a MW of 46 kD found sometimes in association with Cytokeratin 7. Cytokeratin 17 is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type Pachyonychia Congenita and Steatocystoma Multiplex.
Cytokeratin 17 antibody has been used to distinguish immature Cervical Squamous Metaplasia from High Grade Cervical Intraepithelial Neoplasia (CIN III). Anti-CK 17 also labels myoepithelial cells in the benign breast tissue. CK 17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK 5&6, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. CK 17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20% of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK 17. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK 17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
Presentation
Cytokeratin 17 antibody (CK17 antibody) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: keratin 17, KRT17, anti-Cytokeratin 17, anti Cytokeratin 17, anti-KRT17, anti KRT17, anti-Keratin 17, anti Keratin 17, K17, CK17, CK-17, CK 17, anti ck17, anti-ck17, anti ck-17, anti-ck 17
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 2726 | $134.00 |
Presentation: 7 ml Predilute | BSB 2727 | $201.00 |
Presentation: 15 ml Predilute | BSB 2728 | $404.00 |
Presentation: .1 ml Concentrate | BSB 2729 | $118.00 |
Presentation: .5 ml Concentrate | BSB 2730 | $310.00 |
Presentation: 1 ml Concentrate | BSB 2731 | $540.00 |
Presentation: Control Slides [5] | BSB-9137-CS | $77.00 |
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