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FOXA1 / HNF-3A (Polyclonal), RPab

Presentation:

Price: $272.00

SKU:	BSB 2908
Antibody type:	Rabbit Polyclonal
Clone:	Polyclonal
Isotype:	IgG
Concentrate Dilution:	1:25-1:100
Localization:	Cytoplasmic, Nuclear
Tissue Control:	Prostate, Breast, Tonsil, Colon
Species Reactivity:	Human, Mouse

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. FOXA1 is a downstream target of GATA3 in the mammary gland.

FOXA1 antibody expression in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 absence in ERα+ cancer might identify ERa cancers that are resistant to endocrine therapy. In ERα− breast cancer, FOXA1 is highly correlated with improved disease free survival and GATA3. Expression in ERα− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment.

Presentation

FOXA1 antibody is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: forkhead box A1, FOXA1, HNF3A, sc101058, HNF-3α, HNF-3alpha, HNF-3 alpha, HNF-3a, HNF-3 a, HNF 3α, HNF3α, anti-HNF-3α, anti HNF-3α, anti-HNF 3α, anti-HNF3α, anti HNF 3α, anti HNF3α, anti-FOXA1, anti FOXA1, anti-HNF3A, anti HNF3A, anti-forkhead box A1, anti forkhead box A1, Forkhead box protein A1, hepatocyte nuclear factor 3 alpha, HNF 3 alpha, HNF 3A, MGC33105, TCF3A, fork head domain, hepatocyte nuclear factor 3 alpha winged helix transcription factor, TCF 3A, HNF3, Transcription factor 3A

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 2908	$272.00
Presentation: 7 ml Predilute	BSB 2909	$410.00
Presentation: 15 ml Predilute	BSB 2910	$683.00
Presentation: .1 ml Concentrate	BSB 2911	$272.00
Presentation: .5 ml Concentrate	BSB 2912	$548.00
Presentation: 1 ml Concentrate	BSB 2913	$956.00
Presentation: Control Slides [5]	BSB-9182-CS	$77.00