FOXP1 (EP137), RMab

Summary and Explanation

FOXP1 is part of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in regulation of tissue- and cell-type specific gene transcription during both development and adulthood. The FOXP1 protein contains both DNA-binding- and protein-protein binding-domains. FOXP1 is a transcriptional repressor and is responsible for regulating a variety of important aspects of development including tissue development of the lungs, brain, thymus and heart. It is also important in muscle development of the esophagus and esophageal epithelium and for regulating lung airway morphogenesis.

Strong expression of FOXP1 antibody is associated with poor disease-free survival and transformation to Diffuse Large B-cell Lymphomas. Recently, studies suggested a role of FOXP1 in the regulation of ER expression. FOXP1 expression is correlated with ER expression and improved survival in breast cancer patients. Nuclear expression of FOXP1 is associated with ER expression, while cytoplasmic expression of FOXP1 is linked to myometrial invasion in endometrial cancer.