Helicobacter Pylori (BSB-37), MMab

Summary and Explanation

Helicobacter pylori is a mouse monoclonal antibody for immunohistochemistry from Bio SB. Helicobacter pylori is a Gram-negative, microaerophilic bacterium found in the stomach, and may be present in other parts of the body, such as the eye. Helicobacter pylori is a helix-shaped Gram-negative bacterium about 3 μm long with a diameter of about 0.5 μm. It is microaerophilic; that is, it requires oxygen, but at lower concentration than is found in the atmosphere. Helicobacter pylori could be present in patients with chronic gastritis and gastric ulcers and is also linked to the development of duodenal ulcers and stomach cancer. However, over 80% of individuals infected with the bacterium are asymptomatic and it may play an important role in the natural stomach ecology. The strain of Helicobacter pylori to which a person is exposed may influence the risk of developing gastric cancer. Strains of Helicobacter pylori that produce high levels of two proteins, vacuolating toxin A (VacA) and the cytotoxin-associated gene A (CagA), appear to cause greater tissue damage than those that produce lower levels or that lack those genes completely. These proteins are directly toxic to cells lining the stomach and signal strongly to the immune system that an invasion is underway. This antibody reacts with Helicobacter pylori on the surface of epithelial cells of infected specimens.