HER2 neu Phospho (EP123), RMab

Summary and Explanation

HER-2 neu Phospho is a rabbit monoclonal antibody for immunohistochemistry from Bio SB. HER2 / ErbB2 is one of four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases .The kinase activity of ErbB2 can be activated without a ligand if it is overexpressed, and by association with other ErbB proteins. Autophosphorylation did not modulate receptor turnover. A Tyr–Phe substitution of ErbB2 Tyr-877 homologous to pp60c-src Tyr-416 did not alter ErbB2 biological and biochemical properties, thus excluding the possibility that phosphorylation of this residue, located in the kinase domain, modulates ErbB2 gp185 catalytic function.

HER-2 neu Phospho Antibody overexpression is seen in 25–30% of all breast cancers, including primary as well as metastatic breast tumors. HER2 has been widely investigated as a prognostic indicator. Detection of phosphorylated HER-2 neu Phospho Antibody may aid in predicting breast cancer progression.