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idh1, anti-idh1, r132h, anti-r132h, idh-1, idh 1, anti-idh-1, anti-idh MAIN

IDH1 R132H (RBT-IDH1), RMab

Presentation:

Price: $404.00

SKU:	BSB-3732-3
Antibody type:	Rabbit Monoclonal
Clone:	RBT-IDH1
Isotype:	IgG
Concentrate Dilution:	1:50-1:200
Localization:	Cytoplasmic
Tissue Control:	Glioma
Species Reactivity:	Human

DescriptionDocumentationAsk a QuestionPrice Details

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

IDH1 is an isocitrate dehydrogenase isozymes and encoded by the gene IDH1. IDH1 is involved in the citric acid cycle during glucose metabolism and catalyzes the oxidation of isocitrate to ⍺-ketoglutarate and reduction of NADP+ to NADPH. Both ⍺-ketoglutarate and NADPH play a role in protecting cells from oxidative stress and mitigating oxidative damage. Mutation in residue 132 of IDH1 results in loss of enzymatic function, build up of 2-hydroxyglutarate, and change in histone and DNA methylation.

Mutation of IDH1 is implicated in metaphyseal chondromatosis with aciduria as well as diffused gliomas and a number of neoplasms such as acute myeloid leukemia, acute lymphocytic leukemia, myelofibrosis, intrahepatic cholangiocarcinoma, melanoma, chondroid tumors, and certain rare forms of colonic and prostate carcinomas. However studies have shown that IDH1 mutation is not a direct trigger of oncogenesis, but strongly associated with other tumor-promoting mutations. Screening for IDH1 mutation can provide valuable information on diagnosis and prognosis of glioma. Glioma with IDH1 mutation tend to be less aggressive than glioma without IDH1 mutation

Presentation

IDH1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: idh1, anti-idh1, r132h, anti-r132h, idh-1, idh 1, anti-idh-1, anti-idh

Specification Sheets

IVD

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3732-3	$404.00
Presentation: 7 ml Predilute	BSB-3732-7	$722.00
Presentation: 15 ml Predilute	BSB-3732-15	$1,271.00
Presentation: .1 ml Concentrate	BSB-3732-01	$418.00
Presentation: .5 ml Concentrate	BSB-3732-05	$909.00
Presentation: 1 ml Concentrate	BSB-3732-1	$1,443.00
Presentation: Control Slides [5]	BSB-9230-CS	$154.00

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IDH1 R132H (RBT-IDH1), RMab

Intended Use

Summary and Explanation

Presentation

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