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IL-6 (BSB-140), MMab
| SKU: |
BSB-3707-3 |
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Antibody type:
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Mouse Monoclonal
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Clone:
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BSB-140
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Isotype:
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IgG2b
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Concentrate Dilution:
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1:50-1:200
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Localization:
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Cytoplasmatic, Membranous
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Tissue Control:
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Testis, Lung, Stomach, Kidney, TCC
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Species Reactivity:
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Human
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Interleukin-6 is a cytokine that regulates inflammation pathways of the classic and trans-signaling cascades, often involved in metabolic, autoimmune and inflammatory conditions such as IgA nephropathy, lupus nephritis, and chronic kidney disease. The ligation of IL-6/IL-6R activates the JAK/STAT3 (cell survival and proliferation) and MAPK (cell growth and protein production) signaling pathways. IL-6 participates in autoimmune and inflammatory conditions such as arthritis, where it triggers the differentiation of CD4+ T cells into Th17 helper cells, suppresses differentiation into T regulatory cells, and prevents T helper apoptosis along with IL-2. IL-6 also induces differentiation of monocytes into macrophages and uses follicular T helper cells to induce B cell activation, upregulating IgG production. IL-6 antibody reactivity is often found in immune tissues, podocytes, mesangial cells, endothelial and epithelial cells. Il-6 is important in cancer cell growth and suppression of the immune system in the tumor microenvironment, metastasis and renewal of cancer stem cells.
Presentation
IL-6 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: il-6, il6, anti-il6, anti-il-6, il6 antibody, anti-il-6 antibody, cytokine storm, cytokine storm syndrome, cytokine storm antibody, cytokine storm antibodies, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry, IL 6, IL6, interleukin 6, sc57315, sc-57315, 57315, anti-IL-6, anti IL-6, anti-Il6, anti Il6, anti-IL 6, anti IL 6, anti-Interleukin 6, anti Interleukin 6, Ifnb2, ILg6, Interleukin 6 interferon beta 2
Specification Sheets
Safety Data Sheets
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| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB-3707-3 | $229.00 |
| Presentation: 7 ml Predilute | BSB-3707-7 | $418.00 |
| Presentation: 15 ml Predilute | BSB-3707-15 | $750.00 |
| Presentation: .1 ml Concentrate | BSB-3707-01 | $200.00 |
| Presentation: .5 ml Concentrate | BSB-3707-05 | $464.00 |
| Presentation: 1 ml Concentrate | BSB-3707-1 | $766.00 |
| Presentation: Control Slides [5] | BSB-9241-CS | $154.00 |
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