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INI-1 (25), MMab

Presentation:

Price: $212.00

SKU:	BSB 6828
Antibody type:	Mouse Monoclonal
Clone:	25
Isotype:	IgG2a
Concentrate Dilution:	1:25-1:100
Localization:	Nuclear
Tissue Control:	Testis, Brain, Breast, Colon
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/ SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratenorial primitive neuroectodermal tumors (sPNETs)) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.

Presentation

INI-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Specification Sheets

IVD - CE

RUO

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Prediluted	BSB 6828	$212.00
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