LMO2 (RBT-LM02), RMab

Summary and Explanation

LIM domain only 2 (rhombotin-like 1), also known as LIM Domain Only Protein 2 and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene. LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.

HGAL antobody and LMO2 antibody have been found helpful in classifying difficult cases of Follicular Lymphoma (FL) as an adjunct in the identification of FL of the nongastric GI tract. LMO2 expression has been reported to be special feature of GC DLBCL (Diffuse Large B Cell Lymphoma of germinal center subtype) which can be used as a diagnostic marker.  LMO2 antibody has shown usefulness as part of an IHC panel of germinal center-associated markers in eliminating cases of Diffuse Follicle Center Lymphoma. This is accomplished by taking into consideration the histologic and immunoarchitectural spectrum of Nodal Marginal Zone Lymphoma (NMZL) and the immunohistochemical analysis for CD43, CD23, CD21, BCL6, HGAL, and LMO2 in the diagnosis of NMZL.