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MUC5AC (CLH2), MMab
SKU: |
BSB 6163 |
Antibody type:
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Mouse Monoclonal
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Clone:
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CLH2
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Isotype:
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IgG1
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Concentrate Dilution:
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1:25-1:100
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Localization:
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Cytoplasmic
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Tissue Control:
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Stomach, Colon, Kidney
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Species Reactivity:
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Human
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Mucin 5AC, also known as MUC5AC, is a human gene. The Mucin 5AC antigen is found in columnar mucous cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon cells. Mucin genes are expressed in a regulated cell- and tissue-specific manner. MUC1 is detected in mucous cells of the surface epithelium and neck region of the gastric antrum, as well as in pyloric glands and oxynthic glands of the body region. MUC5AC antibody is highly expressed in foveolar epithelium of both body and antrum, whereas MUC6 protein expression is limited to mucous neck cells of the body and pyloric glands of the antrum.
The mucin expression pattern of Gastric Carcinoma is heterogeneous. It includes mucins normally expressed in gastric mucosa (MUC1, MUC5AC and MUC6) and de novo expression of the intestinal mucin MUC2. The heterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of Gastric Carcinoma. It has been shown that in Gastric Carcinomas evaluated for expression of several mucins (MUC1, MUC2, MUC5AC and MUC6), mucin expression is associated with tumor type (MUC5AC with Diffuse and Infiltrative Carcinomas and MUC2 with Mucinous Carcinomas) but not with the clinico-biological behavior of the tumors. Mucin expression is associated with tumor location (MUC5AC with Antrum Carcinomas and MUC2 with Cardia Carcinomas), indirectly reflecting differences in tumor differentiation according to tumor location.
Presentation
MUC5AC antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated,dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: Muc5ac, anti-Mucin 5AC, anti Mucin 5AC, anti-MUC5AC, anti MUC5AC, mucin 5, subtypes A and C, tracheobronchial/gastric, anti-mucin 5, subtypes A and C, tracheobronchial/gastric, anti mucin 5, subtypes A and C, tracheobronchial/gastric, gastric mucin, LeB, Lewis B blood group antigen, Major airway glycoprotein, MUC5, mucin 5 subtypes A and C tracheobronchial gastric, mucin 5AC, mucin 5AC oligomeric mucus gel forming, Mucin 5 subtype AC tracheobronchial, TBM, tracheobronchial mucin, 2210005L13Rik, MGM, mucin 5 subtypes A and C tracheobronchial gastric precursor
Specification Sheets
Safety Data Sheets
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 6163 | $171.15 |
Presentation: 7 ml Predilute | BSB 6164 | $313.95 |
Presentation: 15 ml Predilute | BSB 6165 | $547.05 |
Presentation: .1 ml Concentrate | BSB 6166 | $136.50 |
Presentation: .5 ml Concentrate | BSB 6167 | $336.00 |
Presentation: 1 ml Concentrate | BSB 6168 | $547.05 |
Presentation: Control Slides [5] | BSB 6169 | $67.00 |
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