Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Oct-4 (octamer-binding transcription factor 4) also known as POU5F1 (POU domain, class 5, transcription factor 1) is a protein that in humans is homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells. Clear cell carcinoma may enter the differential diagnosis of dysgerminoma as both may grow in nests or tubules, contain clear cells, and have a prominent inflammatory infiltrate (lymphocytes in dysgerminoma and plasma cells in clear cell carcinoma).
Expression of the OCT-4 antibody is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies. OCT- 4 is expressed in undifferentiated pluriopotency cells, germ cells in ovary and testes. OCT-4 is a sensitive and specific marker for germ cell tumors. It is consistently detected in carcinoma in situ/gonadoblastoma, seminomas, germinoma, dysgerminoma, and embryonal carcinoma but not in the differentiated components of nonseminomas.
Presentation
OCT4 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: Oct 3/4, Oct3/4, anti Oct 3/4, anti Oct-3/4, anti Oct3/4, anti OCT4, POU5F1, anti-Oct 3/4, anti-Oct-3/4, anti-Oct3/4, anti-OCT4, POU5F1, OCT4, POU5F1, MGC22487, Oct 3, Oct 4, OCT3, OCT4, octamer binding protein 3, octamer binding protein 4, Octamer binding transcription factor 3, OTF 3, OTF3, OTF4, POU class 5 homeobox 1, POU domain transcription factor OCT4, POU domain class 5 transcription factor 1, POU type homeodomain containing DNA binding protein, anti-oct-4, anti oct-4, anti-oct4, anti oct4, anti-oct 4, anti oct 4
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| Presentation: 3 ml Predilute | BSB-3830-3 | $305.00 |
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