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p14 ARF (RBT-p14), RMab
SKU: |
BSB 3595 |
Antibody type:
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Rabbit Monoclonal
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Clone:
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RBT-p14
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Isotype:
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IgG
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Concentrate Dilution:
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1:25-1:100
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Localization:
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Cytoplasmic
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Tissue Control:
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Cervical, Anal and Ovarian Carcinoma
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Species Reactivity:
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Human
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
p14 ARF (also called ARF tumor suppressor, ARF, p14ARF) encoded by the p16 tumor suppressor gene is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF accumulates mainly in the nucleolus where it forms stable complexes with NPM or MDM2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting ribosomebiogenesis or initiating p53-dependent cell cycle arrest and apoptosis, respectively. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits MDM2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in MDM2 and, therefore, loss of p53 function and cell cycle control. p14 ARF antibody, has been reported to be associated with the clinicopathological features of different cancers. Very commonly, cancer is associated with a loss of function of INK4a, ARF, Rb, or p53. Without ARF, MDM2 can inappropriately inhibit p53, leading to increased cell survival. The INK4a/ARF locus is found to be deleted or silenced in many kinds of tumors. It has been found that 41% breast carcinomas have p14ARF defects and in a separate study, 32% of colorectal adenomas were found to have p14ARF inactivation due to hypermethylation of the promoter. Homozygous deletions and other mutations of CDK2NA (ARF) have been found to be associated with Glioblastoma. p14ARF expression has been found to be significantly associated with the risk of lung cancer.
Presentation
P14 ARF antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is
concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA
and sodium azide as a preservative.
Synonyms: CDKN2A, anti CDKN2A, anti p14 ARF, anti-CDKN2A, anti-p14 ARF, ARF, CDKN2, CMM2, INK4, INK4A, MLM, MTS 1, MTS1, P14, P14ARF, P16, P16 INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
Specification Sheets
Safety Data Sheets
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 3595 | $295.00 |
Presentation: 7 ml Predilute | BSB 3596 | $537.00 |
Presentation: 15 ml Predilute | BSB 3597 | $961.00 |
Presentation: .1 ml Concentrate | BSB 3598 | $325.00 |
Presentation: .5 ml Concentrate | BSB 3599 | $869.00 |
Presentation: 1 ml Concentrate | BSB 3600 | $1,313.00 |
Presentation: Control Slides [5] | BSB 3601 | $77.05 |
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