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p53 (DO7), MMab
| SKU: |
BSB 5841 |
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Antibody type:
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Mouse Monoclonal
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Clone:
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DO7
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Isotype:
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IgG2b/K
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Concentrate Dilution:
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1:250-1:1000
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Localization:
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Nuclear
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Tissue Control:
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Lung , Breast, Ovarian, Prostate, Colon Carcinoma
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Species Reactivity:
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Human, Cat, Cattle, Horse, Sheep, Bovine, Monkey
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
p53 (also known as tumor protein 53 [TP53]) is a transcription factor that regulates the cell cycle and, hence, functions as a tumor suppressor. p53 has been described as ”the guardian of the genome”, referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms. It can activate DNA repair proteins when DNA has sustained damage; it can also hold the cell cycle at the G1/S regulation point on DNA damage recognition. It can initiate apoptosis, programmed cell death, if DNA damage proves to be irreparable. p53 is central to many of the cell’s anti-cancer mechanisms. It can induce growth arrest, apoptosis and cell senescence.
Mutations involving p53 antibody expression have been found in a wide variety of malignant tumors, including Breast, Ovarian, Bladder, Colon, Lung, and Melanoma.
Presentation
p53 antibody, clone DO7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: p53 antibody do1, DO1, DO 1, TP53, Trp53, anti-p53, anti p53, anti-TP53, anti-Trp53, anti TP53, anti Trp53, anti tumor suppressor protein p53, anti-tumor suppressor protein p53, tumor suppressor protein p53, CI 42kD, complex I 42kD, NADH dehydrogenase ubiquinone 1 alpha subcomplex 10 42kDa, NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 10 mitochondrial, NADH ubiquinone oxidoreductase 42 kDa subunit
Specification Sheets
Safety Data Sheets
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| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 5841 | $147.00 |
| Presentation: 7 ml Predilute | BSB 5842 | $266.70 |
| Presentation: 15 ml Predilute | BSB 5843 | $410.55 |
| Presentation: .1 ml Concentrate | BSB 5844 | $129.15 |
| Presentation: .5 ml Concentrate | BSB 5845 | $310.80 |
| Presentation: 1 ml Concentrate | BSB 5846 | $501.90 |
| Presentation: Control Slides [5] | BSB 5847 | $67.00 |
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