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p53 (DO7), MMab

Presentation:

Price: $140.00

SKU:	BSB 5841
Antibody type:	Mouse Monoclonal
Clone:	DO7
Isotype:	IgG2b/K
Concentrate Dilution:	1:250-1:1000
Localization:	Nuclear
Tissue Control:	Lung , Breast, Ovarian, Prostate, Colon Carcinoma
Species Reactivity:	Human, Cat, Cattle, Horse, Sheep, Bovine, Monkey

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

p53 (also known as tumor protein 53 [TP53]) is a transcription factor that regulates the cell cycle and, hence, functions as a tumor suppressor. p53 has been described as ”the guardian of the genome”, referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms. It can activate DNA repair proteins when DNA has sustained damage; it can also hold the cell cycle at the G1/S regulation point on DNA damage recognition. It can initiate apoptosis, programmed cell death, if DNA damage proves to be irreparable. p53 is central to many of the cell’s anti-cancer mechanisms. It can induce growth arrest, apoptosis and cell senescence. Mutations involving p53 have been found in a wide variety of malignant tumors, including Breast, Ovarian, Bladder, Colon, Lung, and Melanoma.

Presentation

p53 clone DO7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Specification Sheets

IVD - CE

RUO

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Prediluted	BSB 5841	$140.00
Presentation: 7 ml Prediluted	BSB 5842	$254.00
Presentation: 15 ml Prediluted	BSB 5843	$391.00
Presentation: .1 ml Concentrated	BSB 5844	$123.00
Presentation: .5 ml Concentrated	BSB 5845	$296.00
Presentation: 1 ml Concentrated	BSB 5846	$478.00
Presentation: Control Slides [5]	BSB 5847	$63.00