|
|
p53 (DO7), MMab
SKU: |
BSB 5841 |
Antibody type:
|
Mouse Monoclonal
|
Clone:
|
DO7
|
Isotype:
|
IgG2b/K
|
Concentrate Dilution:
|
1:250-1:1000
|
Localization:
|
Nuclear
|
Tissue Control:
|
Lung , Breast, Ovarian, Prostate, Colon Carcinoma
|
Species Reactivity:
|
Human, Cat, Cattle, Horse, Sheep, Bovine, Monkey
|
|
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
p53 (also known as tumor protein 53 [TP53]) is a transcription factor that regulates the cell cycle and, hence, functions as a tumor suppressor. p53 has been described as ”the guardian of the genome”, referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms. It can activate DNA repair proteins when DNA has sustained damage; it can also hold the cell cycle at the G1/S regulation point on DNA damage recognition. It can initiate apoptosis, programmed cell death, if DNA damage proves to be irreparable. p53 is central to many of the cell’s anti-cancer mechanisms. It can induce growth arrest, apoptosis and cell senescence.
Mutations involving p53 antibody expression have been found in a wide variety of malignant tumors, including Breast, Ovarian, Bladder, Colon, Lung, and Melanoma.
Presentation
p53 antibody, clone DO7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: p53 antibody do1, DO1, DO 1, TP53, Trp53, anti-p53, anti p53, anti-TP53, anti-Trp53, anti TP53, anti Trp53, anti tumor suppressor protein p53, anti-tumor suppressor protein p53, tumor suppressor protein p53, CI 42kD, complex I 42kD, NADH dehydrogenase ubiquinone 1 alpha subcomplex 10 42kDa, NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 10 mitochondrial, NADH ubiquinone oxidoreductase 42 kDa subunit
Specification Sheets
Safety Data Sheets
There are currently no questions about this
product.
Ask a Question
Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 5841 | $174.00 |
Presentation: 7 ml Predilute | BSB 5842 | $314.00 |
Presentation: 15 ml Predilute | BSB 5843 | $484.00 |
Presentation: .1 ml Concentrate | BSB 5844 | $152.00 |
Presentation: .5 ml Concentrate | BSB 5845 | $365.00 |
Presentation: 1 ml Concentrate | BSB 5846 | $591.00 |
Presentation: Control Slides [5] | BSB 5847 | $77.05 |
|
|
|