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p63 (4A4), MMab

Presentation:

Price: $228.00

SKU:	BSB 3602
Antibody type:	Mouse Monoclonal
Clone:	4A4
Isotype:	IgG2a/K
Concentrate Dilution:	1:50-1:200
Localization:	Nuclear
Tissue Control:	Prostate, Breast, Skin, Salivary Gland
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

In addition to p53, mammalian cells contain two homologous genes, p63 and p73. These genes give rise to the expression of proteins that are highly similar to p53 in structure and function. In particular, p63 and p73 proteins can induce p53-responsive genes and elicit programmed cell death. p73 and p63 are important during development and differentiation. In particular, p63 appears to be primarily implicated in epithelial development.

Anti-p63 to human p63 protein labels an epitope common to all six p63 isotypes (TAp63α, TAp63β, TAp63γ, ΔNp63α, ΔNp63β, ΔNp63γ). p63 labels the nuclei of myoepithelial cells in the prostate gland as well as breast tissue, making it useful in differentiating benign vs. malignant prostate lesions and breast lesions.

Presentation

p63 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Specification Sheets

IVD - CE

RUO

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Prediluted	BSB 3602	$228.00
Presentation: 7 ml Prediluted	BSB 3603	$413.00
Presentation: 15 ml Prediluted	BSB 3604	$737.00
Presentation: .1 ml Concentrated	BSB 3605	$181.00
Presentation: .5 ml Concentrated	BSB 3606	$327.00
Presentation: 1 ml Concentrated	BSB 3607	$572.00
Presentation: Control Slides [5]	BSB 3608	$63.00