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Parathyroid Hormone / PTH (BSB-24), MMab
SKU: |
BSB 2084 |
Antibody type:
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Mouse Monoclonal
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Clone:
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BSB-24
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Isotype:
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IgG1
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Concentrate Dilution:
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1:250-1:1000
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Localization:
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Cytoplasmatic, Membranous
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Tissue Control:
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Parathyroid
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Species Reactivity:
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Human
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas Calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor (high levels in bone and kidney) and the parathyroid hormone 2 receptor (high levels in the central nervous system, pancreas, testis, and placenta). PTH half-life is approximately 4 minutes.
Parathyroid Hormone antibody is also useful to distinguish parathyroid hyperplasia/neoplasms from thyroid and metastatic neoplasms. If the patient’s hypercalcemic status is not known, PTH immunohistochemistry is helpful, especially if clear cell parathyroid carcinomas are nonsecretory and there is no abnormality in mineral metabolism. The other instance in which anti-PTH antibodies are useful is in the consideration of parathyroid carcinomas located primarily in the anterior mediastinum. In this situation distinction from primary thymic metastatic carcinomas, non-Hodgkin’s lymphoma and germ cell tumors is necessary.
Presentation
Parathyroid Hormone antibody (PTH antibody) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: PTH1R, PTH/PTHrP R, PTH PTHrP R, PTHPTHrP R, PTH, PTHrP R, PTH-R, PTHrP-R, PTHrPR, PTH/PTHrPR, MGC138426, MGC138452, parathyroid hormone 1 receptor, parathyroid hormone receptor 1, Parathyroid hormone parathyroid hormone related peptide receptor, parathyroid hormone parathyroid hormone related protein receptor, PFE, PTH PTHr receptor, PTH PTHrP type I receptor, PTH1 receptor, PTHR, PTHR1, seven transmembrane helix receptor
Specification Sheets
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 2084 | $175.00 |
Presentation: 7 ml Predilute | BSB 2085 | $336.00 |
Presentation: 15 ml Predilute | BSB 2086 | $535.00 |
Presentation: .1 ml Concentrate | BSB 2087 | $164.00 |
Presentation: .5 ml Concentrate | BSB 2088 | $372.00 |
Presentation: 1 ml Concentrate | BSB 2089 | $620.00 |
Presentation: Control Slides [5] | BSB 2090 | $126.00 |
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