For In Vitro Diagnostic Use
Prostate Intraepithelial Neoplasia (PIN) is a pre-cancerous condition of the prostate glands with a high predictive value for adenocarcinoma. An estimated third of men over 50 have a latent form of PIN, which could develop into a higher grade and eventually malignant carcinoma. High Grade (≥2) PIN (HGPIN) has morphological and genetic similarity to prostate adenocarcinomas, and adenocarcinoma presence and multifocality may be associated with the size and number of HGPIN foci.It is well established that the IHC of p63 and CK34BE12 are expressed in basal cells of healthy prostate glands, but mostly absent in adenocarcinoma. AMACR (AlphaMethylacyl CoA Racemase) is expressed in the glands and has been found to be highly expressed in prostate carcinoma and can help to distinguish PIN, a precursor lesion to Prostatic Adenocarcinoma, from benign lesions.The Prostate Intraepithelial Neoplasia (PIN) MultiDetector HRP/AP Kit is a Multiplex triple color IHC Kit designed to detect prostate cancer in situ in the prostate glands. The basal cell indicators (myoepithelial cells with p63 stained with HRP DAB Brown and basal cells with CK34BE12 stained with AP/ ALK Scarlet) stain non-affected glands and the AMACR stained with HRP Green shows prostate tissue that may be affected by Prostatic Adenocarcinoma.
The PIN MultiDetector HRP/AP Kit contains a p63 MMab prediluted antibody, a CK34BE12 MMab and AMACR RMabprediluted antibody cocktail, ImmunoRetriever with Citrate heat epitope retrieval solution, Peroxidase Blocker solution, AP Blocker solution, a Mouse MultiDetector HRP Label, a Mouse MultiDetector AP and Rabbit MultiDetector HRP cocktail solution, a DAB Buffer and DAB Chromogen solution, an ALK Scarlet Buffer and Scarlet Chromogen solution, an HRP Green Buffer and Chromogen solution, and a Fast ChromoProtector stain protection solution. All the components are buffered and contain proteins, stabilizers, anda non-azide anti-microbial.
BSB-0352-7
7 mL Kit
70 Tests*
BSB-0352-15
15 mL Kit
150 Tests*
BSB-0352-50
50 mL Kit
500 Tests*
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