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PIN MultiDetector HRP/AP Kit

Presentation:

Price: $1,423.10

SKU:	BSB-0352-7

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Prostate Intraepithelial Neoplasia (PIN) is a pre-cancerous condition of the prostate glands with a high predictive value for adenocarcinoma. An estimated third of men over 50 have a latent form of PIN, which could develop into a higher grade and eventually malignant carcinoma. High Grade (≥2) PIN (HGPIN) has morphological and genetic similarity to prostate adenocarcinomas, and adenocarcinoma presence and multifocality may be associated with the size and number of HGPIN foci.It is well established that the IHC of p63 and CK34BE12 are expressed in basal cells of healthy prostate glands, but mostly absent in adenocarcinoma. AMACR (AlphaMethylacyl CoA Racemase) is expressed in the glands and has been found to be highly expressed in prostate carcinoma and can help to distinguish PIN, a precursor lesion to Prostatic Adenocarcinoma, from benign lesions.The Prostate Intraepithelial Neoplasia (PIN) MultiDetector HRP/AP Kit is a Multiplex triple color IHC Kit designed to detect prostate cancer in situ in the prostate glands. The basal cell indicators (myoepithelial cells with p63 stained with HRP DAB Brown and basal cells with CK34BE12 stained with AP/ ALK Scarlet) stain non-affected glands and the AMACR stained with HRP Green shows prostate tissue that may be affected by Prostatic Adenocarcinoma.

Presentation

The PIN MultiDetector HRP/AP Kit contains a p63 MMab prediluted antibody, a CK34BE12 MMab and AMACR RMabprediluted antibody cocktail, ImmunoRetriever with Citrate heat epitope retrieval solution, Peroxidase Blocker solution, AP Blocker solution, a Mouse MultiDetector HRP Label, a Mouse MultiDetector AP and Rabbit MultiDetector HRP cocktail solution, a DAB Buffer and DAB Chromogen solution, an ALK Scarlet Buffer and Scarlet Chromogen solution, an HRP Green Buffer and Chromogen solution, and a Fast ChromoProtector stain protection solution. All the components are buffered and contain proteins, stabilizers, anda non-azide anti-microbial.

Components	Catalog No.
	BSB-0352-7 7 mL Kit 70 Tests*	BSB-0352-15 15 mL Kit 150 Tests*	BSB-0352-50 50 mL Kit 500 Tests*
20X ImmunoRetriever with Citrate	50 mL	200 mL	500 mL
MultiDetector Peroxidase Blocker	15 mL	2 x 15 mL	100 mL
MultiDetector AP Blocker	15 mL	2 x 15 mL	100 mL
p63 MMab	7 mL	15 mL	50 mL
CK34BE12 MMab & AMACR RMab	7 mL	15 mL	50 mL
Mouse MultiDetector HRP Label	7 mL	15 mL	50 mL
Mouse MultiDetector AP & Rabbit MultiDetector HRP Label Cocktail	7 mL	15 mL	50 mL
MultiDetector DAB Buffer-Substrate	15 mL	2 x 15 mL	100 mL
MultiDetector DAB Chromogen	1 mL	2 x 1 mL	6 mL
MultiDetector ALK Scarlet BufferSubstrate	15 mL	2 x 15 mL	100 mL
MultiDetector Scarlet Chromogen	1 mL	2 x 1 mL	6 mL
MultiDetector HRP Green Buffer Substrate	15 mL	2 x 15 mL	100 mL
MultiDetector HRP Green Chromogen	1 mL	2 x 1 mL	6 mL
20X ImmunoDNA Washer	200 mL	2 x 200 mL	1000 mL
Fast ChromoProtector	15 mL	50 mL	200 mL
Control Slides	5 Slides	5 Slides	5 Slides

Abbreviated Immunohistochemical Protocol

Specification Sheets

IVD

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 7 mL Kit (70 Tests)	BSB-0352-7	$1,423.10
Presentation: 15 mL Kit (150 Tests)	BSB-0352-15	$2,728.50
Presentation: 50 mL Kit (500 Tests)	BSB-0352-50	$7,730.75

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PIN MultiDetector HRP/AP Kit

Intended Use

Summary and Explanation

Presentation

Abbreviated Immunohistochemical Protocol

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