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Retinoblastoma (1F8), MMab

Presentation:

Price: $157.00

SKU:	BSB 6127
Antibody type:	Mouse Monoclonal
Clone:	1F8
Isotype:	IgG1/K
Concentrate Dilution:	1:25-1:100
Localization:	Nuclear
Tissue Control:	Colon, Breast, Skin, Fallopian Tube
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

The retinoblastoma protein (Rb) is a tumor-suppressor protein that is dysfunctional in many types of cancer. One highly studied function of Rb is to prevent excessive cell growth by inhibiting cell-cycle progression until a cell is ready to divide. Rb prevents the cell from replicating damaged DNA by preventing its progression along the cell cycle through G1 into S.

Should an oncogenic protein (such as that produced by cells infected with high-risk types of human papillomaviruses, SV40 or Adenoviruses) bind and inactivate Rb, this can lead to cancer. Retinoblastoma antibody may act by regulating transcription; loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and Leukemia.

Presentation

Retinoblastoma antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: anti Rb, anti RB1, anti retinoblastoma (RB) transcriptional corepressor 1, anti-Rb, anti-RB1, anti-retinoblastoma (RB) transcriptional corepressor 1, retinoblastoma (RB) transcriptional corepressor 1, OSRC, p105 Rb, pp110, pRb, RB, retinoblastoma 1, retinoblastoma suspectibility protein, Retinoblastoma associated protein

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 6127	$157.00
Presentation: 7 ml Predilute	BSB 6128	$225.00
Presentation: 15 ml Predilute	BSB 6129	$419.00
Presentation: .1 ml Concentrate	BSB 6130	$123.00
Presentation: .5 ml Concentrate	BSB 6131	$391.00
Presentation: 1 ml Concentrate	BSB 6132	$653.00
Presentation: Control Slides [5]	BSB 6133	$63.00