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Smoothelin (R4A), MMab

Presentation:

Price: $258.30

SKU:	BSB 2189
Antibody type:	Mouse Monoclonal
Clone:	R4A
Isotype:	IgG1
Concentrate Dilution:	1:25-1:100
Localization:	Cytoplasmic
Tissue Control:	Leiomyoma, Bladder, Prostate, Myometrium
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Smoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin. To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma.

Strong smoothelin antibody expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task of staging bladder urothelial carcinoma such as in transurethral resection specimens of urinary bladder tumrors. Anti-Smoothelin can also be useful in differentiationg between benign (+) and malignant smooth muscle tumors (-).

Presentation

Smoothelin antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: smoothelin, smtn, anti-smtn, anti-smoothelin, anti smoothelin

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 2189	$258.30
Presentation: 7 ml Predilute	BSB 2190	$470.40
Presentation: 15 ml Predilute	BSB 2191	$752.85
Presentation: .1 ml Concentrate	BSB 2192	$183.75
Presentation: .5 ml Concentrate	BSB 2193	$410.55
Presentation: 1 ml Concentrate	BSB 2194	$764.40
Presentation: Control Slides [5]	BSB 2195	$67.00