TFF3 (BSB-181), MMab

Summary and Explanation

Trefoil factor 3 (TFF3) is an estrogen receptor-related gene in breast and ovarian cancer. Data suggests that TFFs can induce IL-10, MAPK, beta catenin, and/or EGFR activation, and TFF3 has also been shown to suppress TNF-alpha expression and regulate STAT3, a major component of cytokine and growth factor signaling pathways. Evidence exists that TFF3 can increase the rheological properties of mucus, and it has been shown to regulate EGFR activation for protection against colitis and gastrointestinal parasites. TFF3 has been identified as an indicator of Barrett’s Esophagus, a premalignant condition indicating predisposition to esophageal adenocarcinoma. In cases of acid reflux, TFF3 and p53 can be used to help identify likely cases of dysplasia. Overexpression of TFF3 has been found to promote proliferation and invasion in Cervical Cancer cells, through the regulation of E-Cadherin. Expression of TFF3 has also been found to be decreased in Colorectal Cancer, and may be a prognostic indicator with less TFF3 expression indicating higher pathologic stages of the tumor.