Thymidylate Synthase (BSB-160), MMab

Summary and Explanation

A study reported Thymidylate synthase antibody expression and gene copy number (GCN) were assayed using IHC and silver in situ hybridization (SISH), respectively, on primary tumors of resected non-small cell lung (NSCLC) patients and concluded that TS PE and GCN vary widely in NSCLC and correlate significantly to each other. TS GCN is higher in SCCs, whereas TS PE does not associate with histological subtypes, clinical features or survival. Variability of Thymidylate synthase antibody expression and GCN may indicate potential benefit from pemetrexed therapy in selected SCC patients. A number of studies have investigated the relationship between thymidylate synthase (TS) expression and survival in colorectal cancer (CRC) patients. Most have reported poorer overall and progression-free survival with high Thymidylate synthase antibody expression. Another study suggests that immunostaining for TS and p53 protein is useful for pretreatment selection of gastric cancer patients unresponsive to S-1/cisplatin chemotherapy.

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Synonyms:thymidylate synthase, anti-thymidylate synthase, ts, anti-ts