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anti-Trimethyl Histone H3, anti Trimethyl Histone H3, unknown, anti-unknown, anti unknown, Histone H3, Histone H3 MAIN

Tri-Methyl-Histone H3(Lys27)/H3K27Me3 (RBT-H3K27Me3), RMab

Presentation:

Price: $220.00

SKU:	BSB-3806-3
Antibody type:	Rabbit Monoclonal
Clone:	RBT-H3K27Me3
Isotype:	IgG
Concentrate Dilution:	1:50-1:200
Localization:	Nuclear
Tissue Control:	Normal and most tumor tissues
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

H3K27me3 is a downstream target of the polycomb repressive complex 2 (PRC2); PRC2 contains evolutionarily conserved proteins essential for regulating gene expression. Gain- or loss-of-function mutations in EZH2, a component of PRC2, have been found in a variety of cancer types such as lymphoma, melanoma, and Myelodysplastic Lymphoma; gain-of-function mutations can result in H3K27Me hyperactivity and chromatin dysregulation.

KDMA6A and B demethylases can act on H3K27Me, and loss-of-function mutations in these proteins have been found in solid and non-solid tumors including types of leukemia, lymphoma, melanoma, renal and bladder cancers, and in Medulloblastoma. As a gene transcription repressor, H3K27me3 has diverse roles in embryogenesis and neoplasia. Loss of H3K27me3 occurs in a significant subset of Malignant Peripheral Nerve Sheath tumors. Other neoplasms may show loss of H3K27me3 expression, such as Meningioma, Radiation Associated Unclassified Sarcoma, Radiation-Associated Angiosarcoma, Dedifferentiated Chondrosarcoma, Melanoma and Merkel Cell Carcinoma, amongst others. Some tumors may exhibit heterogeneous H3K27me3 expression (mosaic pattern).

Synonyms: anti-Trimethyl Histone H3, anti Trimethyl Histone H3, unknown, anti-unknown, anti unknown, Histone H3, Histone H3

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3806-3	$220.00
Presentation: 7 ml Predilute	BSB-3806-7	$330.00
Presentation: 15 ml Predilute	BSB-3806-15	$551.00
Presentation: .1 ml Concentrate	BSB-3806-01	$220.00
Presentation: .5 ml Concentrate	BSB-3806-05	$441.00
Presentation: 1 ml Concentrate	BSB-3806-1	$771.00
Presentation: Control Slides [5]	BSB-9444-CS	$77.00

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Tri-Methyl-Histone H3(Lys27)/H3K27Me3 (RBT-H3K27Me3), RMab

Intended Use

Summary and Explanation

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