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TRPS1, anti-trps1 antibody, anti trps1, TRPS1 shRNA DNA plasmid, TRPS1 shRNA plasmid MAIN

TRPS1 (EP392), RMab

Presentation:

Price: $215.00

SKU:	BSB-3790-3
Antibody type:	Rabbit Monoclonal
Clone:	EP392
Isotype:	IgG
Concentrate Dilution:	1:50-1:200
Localization:	Nuclear
Tissue Control:	Breast, Ductal Breast Carcinoma
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

The trichorhinophalangeal syndrome 1 (TRPS-1) gene belongs to the GATA transcription factor family. TRPS-1 has been identified as a highly prevalent gene in breast cancer, expressed in >90% of estrogen receptor alpha (ERα)+ and ERα− BC subtypes. As of today, the GATA3 tumor marker is commonly used to determine the breast origin for ER-positive and low-grade breast cancer, but is low in sensitivity <20% in metaplastic breast carcinoma such as Triple-Negative Breast Cancer (TNBC). In contrast, TRPS1 and GATA3 had comparable positive expression in ER-positive (98% vs. 95%) and HER2-positive (87% vs. 88%) breast carcinomas, but TRPS1 had higher expression than GATA3 in metaplastic (86% vs. 21%) and nonmetaplastic (86% vs. 51%) TNBC cases.

TCGA data indicated that the (TRPS1) is a specific gene for breast carcinoma across 31 solid tumor types, including all 4 subtypes of breast carcinoma such as ER/PR-positive luminal A and B types, HER2-positive type, and basal-type/TNBC. TRPS1 produced no or little expression in lung, pancreatic, colon, or gastric adenocarcinomas, urothelial, renal, or ovarian carcinomas, or melanoma; it can be concluded that the TRPS1 marker is a sensitive and specific marker for breast cancer and particularly for TNBC.

Synonyms: TRPS1, anti-trps1 antibody, anti trps1, TRPS1 shRNA DNA plasmid, TRPS1 shRNA plasmid

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3790-3	$215.00
Presentation: 7 ml Predilute	BSB-3790-7	$322.00
Presentation: 15 ml Predilute	BSB-3790-15	$538.00
Presentation: .1 ml Concentrate	BSB-3790-01	$215.00
Presentation: .5 ml Concentrate	BSB-3790-05	$431.00
Presentation: 1 ml Concentrate	BSB-3790-1	$753.00
Presentation: Control Slides [5]	BSB-9212-CS	$77.00

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TRPS1 (EP392), RMab

Intended Use

Summary and Explanation

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