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Bax (E63), RMab

Presentation:

Price: $196.00

SKU:	BSB 6078
Antibody type:	Rabbit Monoclonal
Clone:	E63
Isotype:	IgG
Concentrate Dilution:	1:50-1:200
Localization:	Cytoplasmic , Cell Membranous
Tissue Control:	Breast, Tonsil, Cervix, Hodgkin’s Lymphoma
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Bax is a protein of the bcl-2 gene family. It promotes apoptosis by competing with bcl-2 proper. The Bax gene contains a small promoter element that complements a binding domain on the multi-faceted p53 tumor suppressor. Wild-type p53 has been demonstrated to upregulate the transcription of a chimeric reporter plasmid, utilizing the consensus promoter sequence of Bax approx. 50-fold over mutant p53. Mutations in this consensus sequence eliminate transcription of the reporter gene. Thus, it is likely that p53 promotes Bax’s apoptotic faculties in vivo as a primary transcription factor.

Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial mem-branes, inducing mitochondrial damage and cell death in a caspase-independent manner. Bax antibody plays a critical role in the Bax-mediated apoptosis pathway by dimerizing with BclxL, causing the displacement of Bax. The displacement of Bax allows apoptosis to proceed.

Presentation

Bax is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: BAX, BCL2L4, sc7480, sc-7480, 7480, anti-Bax, anti Bax, anti BCL2 associated X, anti BCL2L4, anti-BCL2 associated X, anti-BCL2L4, BCL2 associated X, Dmelanogaster 1 1ogre gene for conceptual protein of 1 1ogre locus BAX, Dmelanogaster 1 1 ogre gene for conceptual protein of 1 1 ogre locus BAX, Apoptosis regulator BAX, bcl 2 like protein 4

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 6078	$196.00
Presentation: 7 ml Predilute	BSB 6079	$354.00
Presentation: 15 ml Predilute	BSB 6080	$638.00
Presentation: .1 ml Concentrate	BSB 6081	$218.00
Presentation: .5 ml Concentrate	BSB 6082	$479.00
Presentation: 1 ml Concentrate	BSB 6083	$729.00
Presentation: Control Slides [5]	BSB-9026-CS	$77.00