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bcl-10 (BSB-22), MMab
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BSB 2698 |
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Antibody type:
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Mouse Monoclonal
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Clone:
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BSB-22
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Isotype:
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IgG1/K
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Concentrate Dilution:
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1:100-1:500
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Localization:
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Cytoplasmic, Nuclear
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Tissue Control:
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Tonsil, Spleen, Thymus, MALT Lymphomas
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Species Reactivity:
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Human
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Bcl-10 (also known as B-cell lymphoma/leukemia 10) is a 233 amino acid protein encoded by the BCL10 gene on Chromosome 1. The protein encoded by this gene contains a caspase recruitment domain , and has been shown to induce apoptosis and activate NF-kappaB. This protein is reported to interact with caspase recruitment domains (CARD) containing proteins including CARD9, 10, 11 and 14. These proteins function as upstream regulators in NF-kappaB signaling.
Studies have shown that bcl-10 plays a critical role in the development of mucosa associated lymphoma tissue (MALT) lymphoma, and can be utilized in the classification of lymphomas. Bcl-10 antibody antibody labels subpopulations of normal B and T cells. In MALT lymphomas with the t(1;14) translocation, the antibody strongly labeled the nuclei and cytoplasm, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
Presentation
Bcl-10 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: bcl10, anti-bcl10, anti-bcl-10, BCL10, anti-Bcl10, anti Bcl10, BCL10 immune signaling adaptor, anti-BCL10 immune signaling adaptor, anti BCL10 immune signaling adaptor, B cell CLL lymphoma 10, B cell lymphoma leukemia 10, Bcl 10, c E10, CARD containing molecule enhancing NF kB, CARD containing apoptotic signaling protein, CARD containing proapoptotic protein, CARD like apoptotic protein, CARMEN, caspase recruiting domain containing protein, cCARMEN, CED 3 ICH 1 prodomain homologous E10 like regulator, Cellular homolog of vCARMEN, cellular E10, CIPER, CLAP, hCLAP, mammalian CARD containing adapter molecule E10, mE10
Specification Sheets
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| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 2698 | $134.00 |
| Presentation: 7 ml Predilute | BSB 2699 | $270.00 |
| Presentation: 15 ml Predilute | BSB 2700 | $540.00 |
| Presentation: .1 ml Concentrate | BSB 2701 | $118.00 |
| Presentation: .5 ml Concentrate | BSB 2702 | $337.00 |
| Presentation: 1 ml Concentrate | BSB 2703 | $674.00 |
| Presentation: Control Slides [5] | BSB-9028-CS | $77.00 |
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