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bcl-2 (BSB-5), MMab

Presentation:

Price: $113.00

SKU:	BSB 5071
Antibody type:	Mouse Monoclonal
Clone:	BSB-5
Isotype:	IgG1/K
Concentrate Dilution:	1:50-1:200
Localization:	Cytoplasmic, Membranous
Tissue Control:	Tonsil, Lymph Node, Breast, Bone Marrow
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

bcl-2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of bcl-2, such as in the case of translocation of bcl-2 to Ig heavy-chain loci, is thought to be the cause of Follicular Lymphoma. Anti-bcl-2 has shown consistent negative reaction on reactive germinal centers and positive staining of neoplastic follicles in Follicular Lymphoma. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. This antibody may also be used in distinguishing between those Follicular Lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2-negative. Anti-bcl-2 has been used as a predictive biomarker for recurrence of Cancer of the Breast and Non-Small-Cell Carcinoma of the Lung.

Presentation

Anti-bcl-2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Specification Sheets

IVD - CE

RUO

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Prediluted	BSB 5071	$113.00
Presentation: 7 ml Prediluted	BSB 5072	$141.00
Presentation: 15 ml Prediluted	BSB 5073	$275.00
Presentation: .1 ml Concentrated	BSB 5074	$109.00
Presentation: .5 ml Concentrated	BSB 5075	$206.00
Presentation: 1 ml Concentrated	BSB 5076	$279.00
Presentation: Control Slides [5]	BSB 5077	$63.00