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Calponin (BSB-20), MMab

Presentation:

Price: $184.00

SKU:	BSB 5120
Antibody type:	Mouse Monoclonal
Clone:	BSB-20
Isotype:	IgG1/K
Concentrate Dilution:	1:50-1:200
Localization:	Cytoplasmic
Tissue Control:	Appendix, Uterus, Breast Ducts
Species Reactivity:	Human, Canine, Feline

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Calponin is a 34 kDa polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth-muscle contraction mechanisms and is restricted exclusively to smooth-muscle tissue. Calponin is a calcium-binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase (which is dependent upon calcium binding to calmodulin) releases the calponin’s inhibition of the smooth-muscle ATPase.

Calponin antibody has been found to be useful in differentiating benign sclerosing lesions of the breast from Carcinoma. Calponin positivity has also been noted in Malignant Myoepithelioma and Pleomorphic Adenoma of Salivary Gland origin, as well as in Angiomatoid Malignant Fibrous Histiocytoma.

Presentation

Calponin antibody (CALP-A6) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: CNN1, calponin 1 basic smooth muscle, HEL S 14, SMCC, Sm Calp, anti-calponin, calponin-1, anti-calponin 1, anti-calponin-1

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 5120	$184.00
Presentation: 7 ml Predilute	BSB 5121	$278.00
Presentation: 15 ml Predilute	BSB 5122	$484.00
Presentation: .1 ml Concentrate	BSB 5123	$152.00
Presentation: .5 ml Concentrate	BSB 5124	$385.00
Presentation: 1 ml Concentrate	BSB 5125	$531.00
Presentation: Control Slides [5]	BSB-9053-CS	$101.00