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CD74 (LN2), MMab

Presentation:

Price: $100.00

SKU:	BSB 5295
Antibody type:	Mouse Monoclonal
Clone:	LN2
Isotype:	IgG1
Concentrate Dilution:	1:250-1:1000
Localization:	Cytoplasmic, Membranous
Tissue Control:	Tonsil, Lymph Node
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

CD74, also known as the MHC Class II-associated invariant chain (II), is a Type II transmembrane protein which binds to the peptide-binding groove of newly-synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen-presenting cells such as B-lymphocytes (from before the pre-B-cell stage to before the plasma-cell stage), macrophages and monocytes, together with many epithelial cells.

CD74 antibody stains predominantly germinal-center lymphocytes and B-cell lymphomas but rarely T-cell lymphomas. It stains the cell membrane but a paranuclear globular labeling is also noted. CD74 antibody is useful in differentiating Atypical Fibroxanthoma from Malignant Fibrous Histiocytoma, as well as Small-cell Lung Carcinoma from Non-small cell Lung Carcinomas.

Presentation

CD74 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: CD74, HLA class II histocompatibility antigen gamma chain, anti-CD74, anti CD74, anti-HLA class II histocompatibility antigen gamma chain, anti HLA class II histocompatibility antigen gamma chain, CD74 antigen invariant polypeptide of major histocompatibility complex class II antigen associated, CD74 molecule major histocompatibility complex class II invariant chain, DHLAG, gamma chain of class II antigens, HLA DR antigens associated invariant chain, HLA DR gamma, HLADG, Ia antigen associated invariant chain, Ia associated invariant chain, Ia GAMMA, Ii, MHC HLA DR gamma chain, p33, FLJ98970

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 5295	$100.00
Presentation: 7 ml Predilute	BSB 5296	$163.00
Presentation: 15 ml Predilute	BSB 5297	$314.00
Presentation: .1 ml Concentrate	BSB 5298	$123.00
Presentation: .5 ml Concentrate	BSB 5299	$224.00
Presentation: 1 ml Concentrate	BSB 5300	$360.00
Presentation: Control Slides [5]	BSB 5301	$63.00