CD75 (LN-1), MMab

Intended Use

For In Vitro Diagnostic Use

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CD75, also known as CDw75 or Beta-galactoside alpha-2,6-sialyltransferase 1( ST6GAL-1) is an enzyme that in humans is encoded by the ST6GAL1 gene. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76.CD75 is a antibody which labels germinal centre B-cells as well as epithelial cells, however is absent in plasma cells. It reacts with RBC precursors of bone marrow, ductal and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin’s disease. It is shown to be a helpful antibody for ascribing a B-cell phenotype in known lymphoid tissues.