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CD167, DDR1, discoidin domain receptor tyrosine kinase 1, anti-DDR1, anti DDR1, TRK E, TRKE, Tyrosine kinase DDR MAIN

DDR1 (BSB-173), MMab

Presentation:

Price: $210.00

SKU:	BSB-3801-3
Antibody type:	Mouse Monoclonal
Clone:	BSB-173
Isotype:	IgM, kappa
Concentrate Dilution:	1:10-1:50
Localization:	Cytoplasmic
Tissue Control:	Brain, Breast, Colon, Testis
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Discoidin Domain Receptor 1 is a collagen activated receptor tyrosine kinase. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung, where it acts on collagen proteins to remodel the Extracellular Matrix. DDR1 may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts.

Increased expression of DDR1 has been documented in several types of cancer and fibrotic conditions including skin hypertrophic scars, Idiopathic Pulmonary Fibrosis, cirrhotic liver and renal fibrosis. DDR1 was identified as one of the 72 genes that were significantly upregulated in malignant versus benign Pancreatic Cancer, and high levels of DDR1 mRNA were found in Hepatocellular Carcinomas, which significantly correlated with advanced tumor stage. Overexpression of DDR1 in Lung Cancer cells resulted in a significant increase of cell motility and invasiveness, therefore, poor prognosis for the patients. Dysregulation of DDR1 can cause changes in the ECM that impede drug delivery to tumors, and under-expression of DDR1 is correlated with tissue and organ atrophy.

Synonyms: CD167, DDR1, discoidin domain receptor tyrosine kinase 1, anti-DDR1, anti DDR1, TRK E, TRKE, Tyrosine kinase DDR

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3801-3	$210.00
Presentation: 7 ml Predilute	BSB-3801-7	$315.00
Presentation: 15 ml Predilute	BSB-3801-15	$526.00
Presentation: .1 ml Concentrate	BSB-3801-01	$210.00
Presentation: .5 ml Concentrate	BSB-3801-05	$421.00
Presentation: 1 ml Concentrate	BSB-3801-1	$736.00
Presentation: Control Slides [5]	BSB-9439-CS	$77.00

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DDR1 (BSB-173), MMab

Intended Use

Summary and Explanation

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