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Factor VIII-Related Antigen (Polyclonal), RPab
SKU: |
BSB 5498 |
Antibody type:
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Rabbit Polyclonal
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Clone:
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Polyclonal
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Isotype:
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IgG
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Concentrate Dilution:
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1:50-1:200
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Localization:
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Cytoplasmatic
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Tissue Control:
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Skin, Placenta
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Species Reactivity:
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Human, Dog, Cat
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Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Factor VIII (F VIII) is an essential clotting factor. The lack of normal F VIII causes Hemophilia A, an inherited bleeding disorder. FVIII is a glycoprotein procofactor synthesized and released into the bloodstream by the liver. In the circulating blood, it is mainly bound to von Willebrand factor (vWF, also known as Factor VIII-related antigen) to form a stable complex. Upon activation by thrombin or Factor Xa, it dissociates from the complex to interact with Factor IXa, the coagulation cascade. It is a cofactor to Factor IXa in the activation of Factor X, which, in turn, with its cofactor Factor Va, activates more thrombin. Thrombin cleaves fibrinogen into fibrin which polymerizes and crosslinks (using Factor XIII) into a blood clot.
Factor VIII antibody reacts with endothelial cells in normal, reactive, and neoplastic blood cells. F VIII antibody has helped to establish the endothelial nature of some lesions of disputed histogenesis, e.g., Kaposi`s Sarcoma and Cardiac Myxoma. Not all endothelial cells synthesize (or store) this molecule; therefore, it should not be surprising that not all tumors of endothelial differentiation (benign or malignant) react with this antigen.
Presentation
Factor VIII antibody is a purified immunoglobulin fraction of rabbit antiserum, diluted in phosphate buffered saline, pH 7.6, with protein, and preserved with sodium azide.
Synonyms: Coagulation factor VIII, F8, FVIII, anti-Factor VIII, anti Factor VIII, Factor 8, anti-Factor 8, anti Factor 8, anti-F8, anti F8, anti-coagulation factor VIII, anti coagulation factor VIII, anti-FVIII, anti FVIII, AHF, Antihemophilic factor, coagulation factor VIII procoagulant component, coagulation factor VIIIc, DXS1253E, F8B, F8C, Factor VIII B chain, factor VIII F8B, Factor VIIIa heavy chain 200 kDa isoform, Factor VIIIa heavy chain 92 kDa isoform, Factor VIIIa light chain, HEMA, Procoagulant component, F 8
Specification Sheets
Safety Data Sheets
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Option | SKU | Price |
Presentation: 3 ml Predilute | BSB 5498 | $102.90 |
Presentation: 7 ml Predilute | BSB 5499 | $174.30 |
Presentation: 15 ml Predilute | BSB 5500 | $307.65 |
Presentation: .1 ml Concentrate | BSB 5501 | $110.25 |
Presentation: .5 ml Concentrate | BSB 5502 | $148.05 |
Presentation: 1 ml Concentrate | BSB 5503 | $240.45 |
Presentation: Control Slides [5] | BSB 5504 | $67.00 |
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