Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Fibrinogen (factor I) is a glycoprotein that circulates in the blood of vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and subsequently to a fibrin-based blood clot. Fibrinogen functions primarily to occlude blood vessels and there by stop excessive bleeding. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby functions to promote tissue revascularization, wound healing, and tissue repair.
Several disorders (Congenital afibrinogenemia,hypofibrinogenemia, Fibrinogen storage disease, Hereditaryfibrinogen Aα-Chain amyloidosis, Congenital hypodys fibrinogenemia, Cryofibrinogenemia, acquired hypofibrinogenemia, Chronic Kidney Disease, etc.) in the quantity and/or quality of fibrinogen cause pathological bleeding, pathological blood clotting, and/or the deposition of fibrinogen in the liver, kidneys, and other tissues. Chronic kidney disease (CKD) patients have increased rates of bleeding as well as thrombosis. Fibrinogen and platelets combine to generate a mature clot, but in CKD platelets are dysfunctional.
Presentation
The Fibrinogen/FITC is a purified rabbit polyclonal antibody labeled with FITC diluted in a Tris Buffered Saline solution (pH 7.2) containing stabilizing proteins and preserved withsodium azide. It is provided in liquid form.
