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ifn-a, anti-ifn-a, ifna, anti-ifna, ifn a, anti-ifn a, IFN-α, anti-IFN-α, inf alpha, ifn-alpha, anti-ifn-alpha MAIN

IFN-α (BSB-158), MMab

Presentation:

Price: $202.00

SKU:	BSB-3733-3
Antibody type:	Mouse Monoclonal
Clone:	BSB-158
Isotype:	IgG2b
Concentrate Dilution:	1:25-1:100
Localization:	Cytoplasmic, Membranous
Tissue Control:	Placenta, Fallopian Tube, Stomach
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Type I interferons are a large subgroup of interferon proteins that help regulate the immune system by binding to IFN-⍺ receptors. IFN-⍺ (IFN-a) is produced mainly by plasmacytoid dendritic cells and involved in innate immunity against viral infections. Binding of IFN-⍺ to its receptor leads to downstream signalling and expression of numerous different IFN-stimulated genes. These genes encode antiviral proteins that directly inhibit viral replication as well as modulate immune function.

Studies have shown IFN-a strongly modulates innate and adaptive immune responses in the host by enhancing the proliferation, cytotoxicity and IFN-γ secretion of NK cells, as well as acting as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus which causes fever. It does this by binding to opioid receptors and eliciting the release of prostaglandin-E2. IFN-a can also interact with the μ-opioid receptor to act as an analgesic. Additionally, recent studies have shown that Type 1 IFNs stimulate secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with compromised effector T cell generation and trafficking. Type 1 IFNs also induce MHC class 1 upregulation on tumor cells which can enhance antitumor CD8 T cell effector response in the tumor microenvironment.

Synonyms: ifn-a, anti-ifn-a, ifna, anti-ifna, ifn a, anti-ifn a, IFN-α, anti-IFN-α, inf alpha, ifn-alpha, anti-ifn-alpha

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3733-3	$202.00
Presentation: 7 ml Predilute	BSB-3733-7	$363.00
Presentation: 15 ml Predilute	BSB-3733-15	$639.00
Presentation: .1 ml Concentrate	BSB-3733-01	$211.00
Presentation: .5 ml Concentrate	BSB-3733-05	$458.00
Presentation: 1 ml Concentrate	BSB-3733-1	$727.00
Presentation: Control Slides [5]	BSB-3733-CS	$77.05

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IFN-α (BSB-158), MMab

Intended Use

Summary and Explanation

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