Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
IgE, Immunoglobulin E, is an isotype of antibody only found in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two lightchains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgE's main function is immunity to parasites such as helminths like Schistosomamansoni, Trichinella spiralis, and Fasciola hepatica. IgE isutilized during immune defense against certain protozoan parasites such as Plasmodium falciparum.
IgE also has an essential role in type I hypersensitivity, which manifests in various allergic diseases, such as allergic asthma, most types of sinusitis, allergic rhinitis, food allergies, and specific types of chronic urticaria and atopic dermatitis. IgE also plays a pivotal role in responses to allergens, suchas: anaphylactic drugs, bee stings, and antigen preparations used in desensitization immunotherapy. IgE is known to be elevated in various autoimmune disorders such as Lupus (SLE), Rheumatoid Arthritis (RA) & psoriasis, and is theorized to be of pathogenetic importance in RA and SLE by eliciting a hypersensitivity reaction.
Presentation
The IgE/FITC is a purified rabbit polyclonal antibody labeled with FITC diluted in a Tris Buffered Saline solution (pH 7.2) containing stabilizing proteins and preserved with sodium azide. It is provided in liquid form.
