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IgG (BSB-40), MMab

Presentation:

Price: $77.00

SKU:	BSB 5673
Antibody type:	Mouse Monoclonal
Clone:	BSB-40
Isotype:	IgG2a/K
Concentrate Dilution:	1:250-1:1000
Localization:	Cytoplasmic
Tissue Control:	Tonsil, Lymph Node, Kidney, Spleen
Species Reactivity:	Human, Canine, Feline

DescriptionDocumentationAsk a QuestionPrice Details

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

IgG is a monomeric immunoglobulin, built of two heavy chains and two light chains. This is the most abundant immunoglobulin and is approximately equally distributed in blood and tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the placenta and bind to many kinds of pathogens. IgG protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralization of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%). IgG antibody reacts with surface immunoglobulin IgG gamma chains. This antibody is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.

Presentation

IgG antibody is the purified immunoglobulin fraction of rabbit antiserum, diluted in Phosphate Buffered Saline, pH 7.6, with protein base, and preserved with Sodium Azide preservative.

Specification Sheets

IVD - CE

RUO

Safety Data Sheets

SDS

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