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IgM (BSB-41), MMab

Presentation:

Price: $77.00

SKU:	BSB 5680
Antibody type:	Mouse Monoclonal
Clone:	BSB-41
Isotype:	IgG1/K
Concentrate Dilution:	1:100-1:500
Localization:	Cytoplasmic
Tissue Control:	Tonsil, Lymph Node, Spleen, Kidney, Colon
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, normally as a pentamer or occasionally as a hexamer. It has a large molecular mass of approximately 900 kDa (in its pentamer form). In germline cells, the gene segment encoding the constant region of the heavy chain is positioned first among other constant region gene segments. For this reason, IgM is the first immunoglobulin expressed by mature B-cells. IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes, and is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.

Presentation

IgM is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Specification Sheets

IVD - CE

RUO

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Prediluted	BSB 5680	$77.00
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Presentation: 15 ml Prediluted	BSB 5682	$224.00
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