IL-1b (BSB-139), MMab

Summary and Explanation

IL-1b has multiple functions as a major pro-inflammatory cytokine regulated by NFKB. The 31 kDa precursor is biologically inactive in the cytosol, and is processed to its active 17 kDa mature form by Caspase 1 in special lysosomes. The beta-barrel cytokine is secreted to participate in pathways of angiogenesis, antigen presentation, adhesion molecule expression, inflammatory cell activity, and expression of matrix degrading enzymes.

IL-1b antibody expression is found in tumor-infiltrating myeloid cells, which then produce VEGF and other angiogenesis-related factors, promoting growth in multiple tumor types. IL-1b has a role in tumor metastasis and helps maintain an inflammatory tumor environment, but has also demonstrated an anti-tumorigenic function in recruiting immune cells and driving activation of the Th1 response against B cell myeloma and lymphoma. Pathogen-Associated Molecular Patterns can also initiate expression of IL-1b antibody, helping to accumulate neutrophils and promote inflammation and fibrosis at the infection site.