|
|
|
|
iNOS (RBT-iNOS), RMab
| SKU: |
BSB 2656 |
|
Antibody type:
|
Rabbit Monoclonal
|
|
Clone:
|
RBT-iNOS
|
|
Isotype:
|
IgG
|
|
Concentrate Dilution:
|
1:25-1:100
|
|
Localization:
|
Cytoplasmic
|
|
Tissue Control:
|
Testis, Adrenal, Lung, Prostate
|
|
Species Reactivity:
|
Human
|
|
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
The inducible isoform iNOS produces large amounts of NO as a defense mechanism. It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack by parasites, bacterial infection, and tumor growth. It is also the cause of septic shock and may play a role in many diseases with an autoimmune etiology. Induction of the high-output iNOS usually occurs in an oxidative environment, and thus high levels of NO have the opportunity to react with superoxide leading to peroxynitrite formation and cell toxicity. These properties may define the roles of iNOS in host immunity, enabling its participation in anti-microbial and anti-tumor activities as part of the oxidative burst of macrophages.
Presentation
iNOS antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: bNOS, nNOS, NOS1, anti-NOS1, anti NOS1, anti bNOS, anti nNos, anti-bNOS, anti-nNos, Constitutive NOS, IHPS1, N NOS, NC NOS, Neuronal NOS, nitric oxide synthase 1 neuronal, Nitric oxide synthase brain, NOS, NOS type I, Peptidyl cysteine S nitrosylase NOS1
Specification Sheets
Safety Data Sheets
There are currently no questions about this
product.
Ask a Question
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 2656 | $206.00 |
| Presentation: 7 ml Predilute | BSB 2657 | $411.00 |
| Presentation: 15 ml Predilute | BSB 2658 | $826.00 |
| Presentation: .1 ml Concentrate | BSB 2659 | $151.00 |
| Presentation: .5 ml Concentrate | BSB 2660 | $411.00 |
| Presentation: 1 ml Concentrate | BSB 2661 | $826.00 |
| Presentation: Control Slides [5] | BSB-9245-CS | $77.00 |
|
|
|
