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lamin-b1, lamin b1, lmnb1, lmn-b1, anti-lamin-b1, anti-lamin b1, anti-lmnb1, anti-lmn-b1 MAIN

Lamin-B1 (RBT-LMB1), RMab

Presentation:

Price: $226.00

SKU:	BSB-3735-3
Antibody type:	Rabbit Monoclonal
Clone:	RBT-LMNB1
Isotype:	IgG
Concentrate Dilution:	1:50-1:200
Localization:	Nuclear
Tissue Control:	Colon, Breast, Fallopian Tube, Tonsil, Testis, TCC
Species Reactivity:	Human, Mouse, Rat

DescriptionDocumentationAsk a QuestionPrice Details

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Lamin-B1 is an intermediate filament protein that in humans is encoded by the gene LMNB1. B-type Lamin along with A-type Lamin line the inner surface of the nuclear envelope and form a dynamic structure that is disassembled and reassembled each time a cell enters mitosis. Lamin-B1 plays a central role in chromatin organization, gene positioning, DNA replication and repair, cell cycle progression, stress responses, proliferation and differentiation.

Lamin-B1 loss is associated with cellular senescence and a broad range of aging-related diseases such as cardiovascular diseases and cancers. Recent studies showed Lamin-B1 deficiency promotes Lung Cancer development and metastasis by epigenetic derepression of RET, as well as malignancy and poor prognosis in Gastric Cancer. It has been observed that Lamin-B1 levels are reduced in Lung Cancer patients compared to normal Lung tissue and that lower expression of Lamin-B1 antibodywas associated with higher tumor grade. The levels of lamin A, on the other hand, were not altered in human Lung Tumors, indicating that the different types of lamins have distinct functions in lung carcinogenesis. Overexpression of Lamin-B1 antibody can also indicate poor prognosis in Colon and Pancreatic Cancers.

Presentation

Lamin-B1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: lamin-b1, lamin b1, lmnb1, lmn-b1, anti-lamin-b1, anti-lamin b1, anti-lmnb1, anti-lmn-b1

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3735-3	$226.00
Presentation: 7 ml Predilute	BSB-3735-7	$404.00
Presentation: 15 ml Predilute	BSB-3735-15	$711.00
Presentation: .1 ml Concentrate	BSB-3735-01	$234.00
Presentation: .5 ml Concentrate	BSB-3735-05	$509.00
Presentation: 1 ml Concentrate	BSB-3735-1	$809.00
Presentation: Control Slides [5]	BSB-9255-CS	$77.00

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Lamin-B1 (RBT-LMB1), RMab

Intended Use

Summary and Explanation

Presentation

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